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Updated: Aug 17, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

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Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and

Giorgio Sodero1, Francesco Mariani1, Michela Caprarelli1

  • 1Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|December 11, 2022
PubMed

Insights

Growth hormone stimulation tests (GHST) in children with short stature revealed lower IGF-1 and higher TSH in growth hormone deficiency (GHD). Metabolic factors like BMI and weight influence GH peaks during testing.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Physiology
  • Metabolic Disorders

Background:

  • Short stature in children necessitates differentiating growth hormone deficiency (GHD) from other causes.
  • Growth hormone stimulation tests (GHST) are crucial diagnostic tools.

Approach:

  • Retrospective analysis of 161 GHSTs in 74 children with short stature.
  • Evaluation of correlations between GH peaks and auxological/metabolic parameters.
  • Comparison between children with GHD and idiopathic short stature.

Key Points:

  • Children with GHD showed significantly lower IGF-1 and higher TSH levels.
  • Triglycerides correlated with GH peak during arginine test.
  • Pre-test BMI and weight influenced GH peak during clonidine stimulation test.

Conclusions:

  • Metabolic and auxological parameters can impact GHST results.
  • These factors must be considered when interpreting GH peak values.
  • Distinguishing GHD from other causes of short stature requires comprehensive assessment.
Abstract

Keywords:
ArginineChildrenClonidineGH deficiencyGHSTGrowth hormone (GH)Personalized medicineShort stature

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