Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Toxins01:36

Types of Toxins

1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.9K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.9K
The Periodic Table and Organismal Elements01:27

The Periodic Table and Organismal Elements

18.5K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
18.5K
The Thyroid Gland01:23

The Thyroid Gland

4.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.1K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

144
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
144

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discrepancy between subjective and objective cognitive function in multiple sclerosis and association with mood, fatigue, and pain.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

Prenatal exposure to persistent organic pollutants and body mass index trajectories from birth to age 13.

Environmental research·2026
Same author

Association between long-term exposure to ambient PM<sub>2</sub><sub>.</sub><sub>5</sub> and NO<sub>2</sub> and cognitive function in the CARTaGENE cohort.

Environmental research·2026
Same author

dsLassoCov: a federated Lasso approach incorporating covariate control.

Scientific reports·2026
Same author

Levers to decrease exposure to harmful chemicals: the case of Personal Care Products and cosmetics.

Environment international·2026
Same author

Structural neuroimaging of the planning network in Inuit adolescents prenatally exposed to lead.

Neurotoxicology·2026

Related Experiment Video

Updated: Aug 17, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

939

Persistent Organic Pollutant Exposure and Thyroid Function among 12-Year-Old Children.

Hélène Tillaut1, Christine Monfort1, Frank Giton2,3

  • 1Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France.

Neuroendocrinology
|December 12, 2022
PubMed
Summary

Persistent organic pollutants (POPs) like PCBs and PFASs are linked to thyroid hormone disruption in children. These effects vary by sex and puberty stage, suggesting complex endocrine interactions.

Keywords:
AdolescencePer- and polyfluoroalkyl substancesPersistent organic pollutantThyroid function

More Related Videos

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K

Related Experiment Videos

Last Updated: Aug 17, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

939
Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.1K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.8K

Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Persistent organic pollutants (POPs), including polychlorobiphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs), are widespread environmental contaminants.
  • These POPs possess toxicological properties, notably endocrine disruption, with potential impacts on thyroid function.

Purpose of the Study:

  • To investigate the associations between exposure to specific PCBs, OCPs, and PFASs and thyroid hormone levels (free tri-iodothyronine [fT3], free thyroxine [fT4], and thyroid-stimulating hormone [TSH]) in 12-year-old children.
  • To examine whether these associations are influenced by pubertal status and sex.

Main Methods:

  • A cross-sectional study involving 249 boys and 227 girls from the PELAGIE mother-child cohort in France.
  • Blood serum levels of 7 PCBs, 4 OCPs, and 6 PFASs were measured.
  • Thyroid hormones (fT3, fT4, TSH) and pubertal status (Tanner stages) were assessed. Associations were analyzed using linear regression, adjusted for confounders.

Main Results:

  • In boys, certain POPs were associated with decreased fT3 and fT4. Associations with decreased TSH and fT3 were observed in boys with more advanced pubertal stages (3-5) and early stages (1-2), respectively.
  • In girls, perfluorohexanesulfonic acid (PFHxS) was linked to decreased TSH, and perfluorooctanoic acid (PFAS) was associated with decreased fT3.
  • Sex-specific effects and moderation by pubertal status were evident for several POP-thyroid hormone relationships.

Conclusions:

  • This study demonstrates associations between exposure to specific POPs and thyroid function disruption in children.
  • The findings suggest that the impact of POPs on thyroid hormones is sex-specific and moderated by pubertal development.
  • Complex endocrine interactions are likely involved in the observed effects, highlighting the need for further research.