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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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From intestinal colonization to systemic infections: Candida albicans translocation and dissemination

Jakob L Sprague1, Lydia Kasper1, Bernhard Hube1,2

  • 1Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany.

Gut Microbes
|December 12, 2022
PubMed

Insights

Candida albicans translocation from the gut causes invasive fungal infections. Understanding these mechanisms can prevent systemic candidiasis and maintain commensalism in at-risk patients.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Microbiology

Background:

  • Invasive fungal infections are primarily caused by Candida species, with Candida albicans being the most frequent pathogen.
  • Candida albicans translocation across the intestinal epithelial barrier is the primary route for systemic candidiasis.
  • Predisposing conditions increase the risk of Candida albicans colonization and subsequent invasive infections.

Conclusions:

  • Understanding Candida albicans translocation is crucial for developing preventative strategies against invasive candidiasis.
  • Targeting fungal translocation mechanisms could help maintain Candida albicans in a commensal state.
  • Further research is needed to fully elucidate the pathways of Candida albicans dissemination.
Keywords:
Candida albicansdisseminationfungigut colonizationintestinal translocation

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