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The unmet need for COVID-19 treatment in immunocompromised patients
Alessandra D'Abramo1, Serena Vita2, Emanuele Nicastri1
1National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, Via Portuense 292, 00149, Rome, Italy.
Background:
Immunocompromised (IC) patients are at increased risk of severe and/or prolonged COVID-19.
Main Text:
The recent study by Scaglione et al., addresses the issue of IC outpatients with SARS-CoV-2 infection. Authors describe the real-life use of SARS-CoV-2 antivirals and/or monoclonal antibodies and the clinical benefit in high-risk COVID-19 patients. The study supports the use of early combination therapy in a subgroup of extremely high risk patients, and considers the combined strategy as a gold standard regimen to both increase the effectiveness of early treatment, especially in IC individuals, and, reduce the emergence of SARS-CoV-2 escape mutants.
Conclusion:
A tailored and standardised therapeutic approach in case of IC out and inpatients with SARS-CoV-2 infection is needed.
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