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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Inheritance of Chromatin Structures03:17

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Pleiotropy01:33

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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X-Inactivation01:58

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The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
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Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
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Related Experiment Video

Updated: Aug 17, 2025

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
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Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases.

Mengru Li1, Lijun Xu1, Rui Zhang1

  • 1College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin 300457, China.

Current Protein & Peptide Science
|December 12, 2022
PubMed
Summary

The ASXL2 protein, a key transcription regulator, is crucial for tumor detection and linked to hematological and heart diseases. Understanding its function and expression aids in developing future disease treatments.

Keywords:
ASXL2diseaseepigenetic regulationfunctionmechanismstructure

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Area of Science:

  • Molecular Biology
  • Oncology
  • Cardiology

Background:

  • The ASXL2 protein functions as a transcription regulator and is a significant area of research for tumor detection.
  • Aberrant ASXL2 protein expression is primarily associated with malignant hematological disorders and heart diseases.

Conclusions:

  • ASXL2 is a promising biomarker for disease detection and prognosis.
  • Further research into ASXL2's role can inform the development of novel therapeutic strategies.
  • A comprehensive understanding of ASXL2 is essential for advancing treatments in oncology and cardiology.