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HIV cure: an acceptability scientific agenda.
Evelyn Y Bonney1, Helena Lamptey2, George B Kyei1,2,3
1Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
Current Opinion in HIV and AIDS
|December 12, 2022
Summary
HIV cure research must include social science and diverse populations. Ensuring acceptability and appropriateness globally is key for effective HIV remission and viral elimination strategies.
Area of Science:
- Medical Research
- Social Sciences
- Public Health
Background:
- Significant investments are being made in human immunodeficiency virus (HIV) cure research.
- The current research agenda primarily focuses on scientific and clinical aspects of achieving a cure, such as functional cure (remission) or complete cure (viral elimination).
Approach:
- This review considers how to broaden the HIV cure research agenda to encompass social science perspectives.
- It examines the differential interpretations of cure definitions across diverse populations.
- The importance of including Africa in cure research is highlighted due to the continent's significant burden of the AIDS pandemic.
Key Points:
- Definitions of HIV cure, including functional and complete cure, may be perceived differently by various populations.
- Different cure methodologies require careful consideration of cultural and social contexts.
- Geographic diversity in research, particularly involving Africa, is crucial for equitable development and deployment of HIV cures.
Conclusions:
- Social science research on HIV cure acceptability should be integrated with basic and clinical sciences.
- Concurrent research ensures that developed cure methods align with stakeholder preferences and are socially appropriate.
- Broadening the research agenda promotes a more inclusive and effective global strategy for HIV cure development.
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