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A near-infrared GPX4 fluorescent probe for non-small cell lung cancer imaging
Qiao Hu1, Wanjie Zhu1, Jianjun Du1,2
1State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China. dujj@dlut.edu.cn.
Chemical Communications (Cambridge, England)
|December 12, 2022
Abstract:
Glutathione peroxidase 4 (GPX4) is overexpressed in non-small cell lung cancer (H1299) cells. In this work, a near-infrared fluorescent probe ENBO-ML210 was developed. In vitro and in vivo imaging results showed that ENBO-ML210 could target and visualize GPX4 in H1299 cells, exhibiting potential for the diagnosis of non-small lung cancer.
