Related Experiment Video
Updated: Aug 17, 2025
Sleeve Gastrectomy in Mice using Surgical Clips
Published on: November 14, 2020
Metabolic and hormonal changes after laparoscopic sleeve gastrectomy in pediatric population: An observational study
Hashim Alghamdi1,2, Ashwag Asiri2,3, Faris Alzahrani4
1Mnistry of Health, Abha Maternity and Children Hospital, Abha, Saudi Arabia.
Insights
Laparoscopic sleeve gastrectomy (SG) improves diabetes and triglyceride levels in adolescents within a year. However, long-term monitoring of nutritional and endocrine factors is recommended as some biomarkers remain unchanged after SG.
Area of Science:
- Pediatric Endocrinology
- Bariatric Surgery Outcomes
- Metabolic Health in Adolescents
Background:
- Laparoscopic sleeve gastrectomy (SG) is increasingly used for severe obesity in pediatric populations.
- Limited studies exist on SG's metabolic and hormonal effects in children and adolescents.
Purpose of the Study:
- To evaluate the 12-month impact of laparoscopic SG on nutritional, metabolic, and endocrine parameters in children aged 5-15 years.
- To assess changes in glucose homeostasis, blood lipids, thyroid hormones, and the hypothalamic-pituitary-adrenal axis post-SG.
Main Methods:
- Retrospective, single-center study of 64 adolescents (mean age 11.2 years) undergoing laparoscopic SG.
- Assessment of nutritional biomarkers, glucose homeostasis indicators, blood lipids, and specific hormone levels preoperatively and at 12 months post-surgery.
Main Results:
- Significant reductions observed in C-peptide, HbA1C, random blood glucose, and triglycerides at 12 months post-SG.
- Adrenocorticotropic hormone levels decreased significantly, while cortisol levels remained unchanged.
- No significant changes were noted in cholesterol components, thyroid hormones, or nutritional biomarkers.
Conclusions:
- Laparoscopic SG effectively improves diabetes and hypertriglyceridemia markers in adolescents within one year.
- Long-term monitoring is crucial for nutritional, metabolic, and endocrine factors post-SG in this population.
- This study is the first to report SG's effects on thyroid and HPA axis hormones in pediatric populations.
Introduction:
Despite the growing popularity of laparoscopic sleeve gastrectomy (SG) for managing severe obesity in children, adolescents, and adults, there is a paucity of studies reporting the effects of SG on metabolic and hormonal outcomes in pediatric populations.
Methodology:
In this single-centre, retrospective study, we assessed nutritional biomarkers (hemoglobin, ferritin, iron profile, Vitamin B12, Vitamin D, and calcium), glucose homeostasis indicators (C-peptide, HbA1C, and random blood glucose), blood lipids (triglycerides and cholesterol components), hormones involved in the hypothalamic-pituitary-adrenal axis (cortisol and adrenocorticotropic hormone), and thyroid hormones (T3, T4, thyroid-stimulating hormone, and parathyroid hormone) preoperatively and 12-month after SG in children aged 5-15 years.
Results:
This study included 64 adolescents (mean age = 11.2 ± 2.3 years) who underwent laparoscopic SG. Significant reduction in circulatory C-peptide (-62.1%; p = 0.005), HbA1C (-10.9%; p = 0.001), random blood glucose (-15.4%; p = 0.036), and triglycerides (-39.4%; p = 0.003) were observed postoperatively at 12 months compared to baseline. Although we did not observe any changes in cortisol levels, adrenocorticotropic hormone levels declined significantly by -40.9% postoperatively (p = 0.033). However, cholesterol components, thyroid hormones, and nutritional biomarkers remained unchanged from baseline.
Conclusions:
Consistent with prior literature, our study demonstrates improvement or resolution of diabetes and hypertriglyceridemia in the year following SG. However, given that blood cholesterol components, nutritional biomarkers, and thyroid profiles remained unchanged warrants long-term monitoring of nutritional, metabolic, and endocrine factors in adolescents undergoing laparoscopic SG. To the best of our knowledge, this is the first study reporting the effects of SG on thyroid and hypothalamic-pituitary-adrenal axis hormones in pediatric populations.
Related Concept Videos
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...