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Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Remote programming for subthalamic deep brain stimulation in Parkinson's disease.

Si Chen¹, Shu-Jun Xu¹, Wei-Guo Li¹

¹Center for Movement Disorders, Qilu Hospital of Shandong University, Jinan, China.

Frontiers in Neurology

|December 12, 2022

Summary

This summary is machine-generated.

Remote programming for deep brain stimulation (DBS) in Parkinson's disease (PD) shows satisfactory results. Different programming modes, including remote and in-person, do not significantly impact STN-DBS effectiveness 12 months post-surgery.

Keywords:

China Parkinson's disease activities of daily living (ADL)deep brain stimulation remote programming subthalamic nucleus

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Area of Science:

Neurology
Neurosurgery
Biomedical Engineering

Background:

Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a key treatment for Parkinson's disease (PD).
Remote programming is increasingly utilized, particularly in regions like Mainland China, necessitating an evaluation of its efficacy.
Assessing the impact of various programming modalities on STN-DBS outcomes is crucial for optimizing patient care.

Purpose of the Study:

To retrospectively evaluate the effectiveness of STN-DBS 12 months postoperatively in Parkinson's disease patients.
To compare the outcomes of different programming modes: remote alone, hospital alone, and combined hospital + remote programming.
To determine if programming modality influences the short-term efficacy of STN-DBS.

Main Methods:

Retrospective analysis of clinical data from 83 Parkinson's disease patients before and 12 months after STN-DBS surgery.
Patients were categorized into three groups based on their chosen programming mode: remote alone, hospital alone, or combined.
Comparison of programming data and STN-DBS effectiveness using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and levodopa equivalent daily dose (LEDD).

Main Results:

STN-DBS effectiveness at 12 months was not significantly influenced by the programming mode used.
No statistically significant differences in postoperative MDS-UPDRS scores were observed between remote and hospital programming groups, except for the motor examination component.
The hospital programming alone group showed the most apparent decline in LEDD, while the combined group had a higher programming frequency.

Conclusions:

Programming modes do not appear to influence the short-term efficacy of STN-DBS for Parkinson's disease.
Remote programming alone can achieve satisfactory surgical effects and is a viable option for PD management.
Further analysis of 76 patients confirmed good overall surgical efficacy of STN-DBS.