Research progress on near-infrared long persistent phosphor materials in biomedical applications

Area of Science:

• Materials Science
• Biomedical Engineering
• Optics

Background:

• Long persistent phosphor materials (LPPs) exhibit light emission after excitation ceases, allowing temporal separation of excitation and emission.
• LPPs are crucial in fields like data storage, information technology, and biomedicine.
• Near-infrared (NIR) LPPs possess unique advantages for biomedical applications, including reduced autofluorescence interference, strong tissue penetration, and excellent afterglow properties.

Purpose of the Study:

• This review focuses on the synthesis methods and luminescence mechanisms of various NIR LPPs.
• It explores the applications of NIR LPPs in bioimaging, biosensing detection, and cancer treatment.
• The review also discusses future prospects and challenges for NIR LPPs in biomedicine.

Main Methods:

• The review synthesizes information on the synthesis of different types of NIR LPPs.
• It analyzes the luminescence mechanisms underlying their persistent emission.
• Existing literature on biomedical applications is critically evaluated.

Main Results:

• NIR LPPs demonstrate significant advancements in bioimaging, sensing, and surgical guidance.
• Their properties facilitate applications requiring deep tissue penetration and minimal autofluorescence.
• Successful applications in cancer treatment have been highlighted.

Conclusions:

• NIR LPPs offer a promising platform for next-generation biomedical technologies.
• Further research into synthesis and mechanism optimization is needed.
• Overcoming current challenges will unlock the full potential of NIR LPPs in clinical settings.