Related Experiment Video

Updated: Aug 17, 2025

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
09:23

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion

Published on: April 2, 2020

6.5K

The roles of KLHL family members in human cancers

Ganghui Ye1,2, Jie Wang1,2, Weili Yang3

  • 1The Affiliated Hospital of Medical School, Ningbo University Ningbo 315020, Zhejiang, P. R. China.

American Journal of Cancer Research
|December 12, 2022
PubMed

Insights

Kelch-like (KLHL) proteins form E3 ubiquitin ligases impacting cancer. This review explores KLHL family roles in tumor regulation, offering insights beyond KLHL19.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Kelch-like (KLHL) proteins, comprising specific domains, interact with Cullin3 to form E3 ubiquitin ligases.
  • These ligases ubiquitinate substrates, regulating crucial physiological and pathological processes, including cancer development and progression.
  • While KLHL19's role in tumorigenesis and drug resistance is known, the functions of other KLHL family members in cancer remain largely unexplored.

Purpose of the Study:

  • To review and synthesize current research on the roles of KLHL family members, excluding KLHL19, in tumor-related regulation.
  • To elucidate the involvement of various KLHL proteins in cancer processes.
  • To provide novel insights into the broader KLHL family's contribution to oncology.

Main Methods:

  • Comprehensive literature search of studies focusing on KLHL family members and their roles in cancer.
  • Analysis and synthesis of findings related to KLHL protein function in tumorigenesis, progression, and drug resistance.
  • Identification of research gaps concerning the regulation and cross-talk of KLHL family members in cancer.

Main Results:

  • KLHL family members are implicated in diverse aspects of cancer, acting as E3 ubiquitin ligases.
  • Specific KLHL proteins influence tumorigenesis, cancer cell proliferation, and response to therapies.
  • Interactions and regulatory networks among KLHL family members in the context of cancer are complex and require further investigation.

Conclusions:

  • The KLHL family represents a significant group of proteins involved in cancer regulation through ubiquitination.
  • Understanding the specific roles and interactions of each KLHL member is crucial for developing targeted cancer therapies.
  • Further research into the broader KLHL family's functions will enhance our comprehension of cancer biology and treatment strategies.
Keywords:
E3 ubiquitin ligaseKelch-like family memberdegradationhuman cancerubiquitination

More Related Videos

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

489
Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro13:20

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro

Published on: July 17, 2018

10.4K

Related Concept Videos

The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.4K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.7K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
4.1K
Cytoskeletal Linker Proteins - Plakins01:09

Cytoskeletal Linker Proteins - Plakins

Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
2.4K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.1K