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Pharmacokinetic Models: Comparison and Selection Criterion01:26

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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In Silico Clinical Trials for Cardiovascular Disease
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Editorial: Methods and applications in computational physiology and medicine

A H Khandoker1, P Castiglioni2, J L Greenstein3

  • 1Department of Biomedical Engineering, Khalifa University, Abu Dhabi, United Arab Emirates.

Frontiers in Physiology
|December 12, 2022
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No abstract available in PubMed .

Keywords:
computationalin silicomedicinemethodsmodellingmultidisciplinaryphysiology

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