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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

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Signaling pathways in cutaneous wound healing

Olga Krizanova1,2,3, Adela Penesova1, Jozef Sokol2

  • 1Institute of Clinical and Translational Research, Biomedical Research Center SAS, Bratislava, Slovakia.

Frontiers in Physiology
|December 12, 2022
PubMed

Insights

Novel wound healing strategies focus on modulating signaling molecules like gasotransmitters and calcium. This approach aims for quicker, more effective healing, especially for chronic wounds and inflammation in diabetes.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Dermatology

Background:

  • Wound healing is a complex biological process involving multiple signaling pathways.
  • Improper healing can lead to chronic wounds, posing significant health challenges.
  • Understanding these pathways is crucial for developing effective therapeutic strategies.

Purpose of the Study:

  • To review novel approaches for cutaneous wound healing.
  • To explore the potential of modulating signaling molecules, specifically gasotransmitters and calcium.
  • To address challenges in chronic wound healing, particularly in diabetes mellitus.

Main Methods:

  • Literature review of current research on wound healing mechanisms.
  • Analysis of the role of gasotransmitters and calcium in cellular processes.
  • Focus on inflammation and its impact on chronic wound resolution.

Main Results:

  • Gasotransmitters act as bioactive signaling molecules with antioxidative properties.
  • Calcium enhances immune function and significantly contributes to the healing process.
  • Modulating these molecules offers new possibilities for treating acute and chronic wounds.

Conclusions:

  • Targeting gasotransmitters and calcium presents promising avenues for advanced wound care.
  • These strategies may improve healing outcomes, particularly for complex cases like diabetic chronic wounds.
  • Further research into these signaling pathways can lead to more effective treatments for inflammation-related wound complications.
Keywords:
calciumdiabetes mellitusgasotransmittershydrogen peroxidewound healing

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