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Genetic Association between Polymorphisms of Interleukin-32 and Dilated Cardiomyopathy in Chinese Han Population

Ying Peng1, Xuemei Zhong1, Yanyun Wang2

  • 1Department of Cardiology, West China Hospital, Sichuan University, No. 37 GuoXue Xiang, Chengdu, Sichuan 610041, China.

Disease Markers
|December 12, 2022
PubMed

Insights

Interleukin-32 gene variations, specifically rs12934561, are linked to an increased risk of dilated cardiomyopathy (DCM) in the Chinese Han population. This finding suggests rs12934561 may help identify individuals at higher risk for DCM.

Area of Science:

  • Genetics
  • Cardiology
  • Immunology

Background:

  • Dilated cardiomyopathy (DCM) is a primary heart muscle disease and a leading cause of heart failure.
  • It is the most common reason for heart transplantation globally.
  • Inflammatory cytokines and immune responses are implicated in DCM pathogenesis, with Interleukin-32 (IL-32) being a key proinflammatory cytokine.

Purpose of the Study:

  • To investigate the association between Interleukin-32 gene polymorphisms (rs12934561 and rs28372698) and susceptibility to dilated cardiomyopathy.
  • To explore the potential of IL-32 gene variants as risk factors for DCM.

Main Methods:

  • Genotyping of two single-nucleotide polymorphisms (SNPs) in the IL-32 gene (rs12934561 and rs28372698) using polymerase chain reaction-restriction fragment length polymorphism.
  • Statistical analysis of data from 418 DCM patients and 437 healthy controls using SPSS software.

Main Results:

  • The C allele and CC genotype of rs12934561 were significantly more frequent in DCM patients (P < 0.001).
  • The A allele and AA genotype of rs28372698 were significantly less frequent in DCM patients (P = 0.004 and P = 0.02).
  • CC homozygotes for rs12934561 showed an increased risk of DCM, particularly in patients with left ventricular ejection fraction ≤ 30% (P = 0.02).

Conclusions:

  • IL-32 gene polymorphisms may contribute to the risk of developing dilated cardiomyopathy in the Chinese Han population.
  • The rs12934561 polymorphism could serve as a predictive factor for identifying individuals at high risk for DCM.
Abstract

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