Diagnostic and prognostic value of coagulation-related factors in endometriosis

To investigate the diagnostic and prognostic values of coagulation-related factors in endometriosis and explore the risk factors for the recurrence after treatment.

Forty-eight patients with endometriosis admitted to the Second Hospital of Shandong University from June 2018 to March 2020 were enrolled in this retrospective analysis, along with 45 of subjects who underwent physical examination as healthy controls. Endometriosis patients were seen as research group (RG) and healthy subjects were considered as control group (CG). Patients in RG were treated with mifepristone. The coagulation-related factors, including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB), were measured, and their diagnostic value in endometriosis as well as their correlation with the mean cyst diameter and the clinical outcomes of patients were analyzed.

APTT, PT, and TT were shortened whereas FIB was increased in the RG as compared with CG (all P<0.05). ROC analysis revealed that coagulation-related factors had an excellent diagnostic value in endometriosis (P<0.05). Subsequently, we found that patients in the RG had higher APTT, PT, and TT and lower FIB after treatment (P<0.05). Moreover, APTT, PT, and TT were prolonged while FIB was decreased in patients with good prognosis as compare with those with poor prognosis (all P<0.05). Correlation analysis denoted that APTT, PT, and TT were negatively correlated with mean cyst diameter, whereas FIB was positively correlated with it (P<0.05). The abortion times and post-treatment TT were independent risk factors for recurrence within 2 years.

Coagulation-related factors are associated with endometriosis. They can effectively assess the treatment efficacy of mifepristone, which has great prospects for future clinical application.