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Association between psoriasis and coronary artery calcification: A systematic review and meta-analysis

Huihui Wu1, Zeyu Luo2, Juanhua Liu1

  • 1Department of Dermatology, The East Division of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Frontiers in Cardiovascular Medicine
|December 12, 2022
PubMed

Insights

Psoriasis is linked to coronary artery calcification (CAC), a marker of atherosclerosis. This association appears stronger in younger individuals, highlighting potential cardiovascular risks in psoriasis patients.

Area of Science:

  • Cardiovascular Medicine
  • Dermatology
  • Inflammatory Diseases

Background:

  • Psoriasis and atherosclerosis share inflammatory pathways.
  • The link between psoriasis and coronary artery calcification (CAC), a key atherosclerosis indicator, requires comprehensive evaluation.
  • This study investigates the association between these inflammatory conditions.

Approach:

  • A systematic review and meta-analysis of observational studies was conducted.
  • PubMed, Cochrane's Library, and Embase databases were searched for relevant studies.
  • A random-effect model was employed to pool data from 16 studies involving over 3,000 patients with psoriasis and 46,000 controls.

Key Points:

  • Psoriasis is significantly associated with the presence of CAC (OR: 1.54, 95% CI: 1.23-1.91).
  • This association remained significant after adjusting for conventional cardiovascular risk factors.
  • A notably stronger association was observed in younger patients (mean age <50 years) compared to older patients.

Conclusions:

  • Psoriasis is independently associated with coronary artery calcification.
  • The findings suggest psoriasis is a risk factor for atherosclerosis.
  • Younger psoriasis patients may face a heightened risk of CAC.
Abstract

Keywords:
atherosclerosiscoronary artery calcificationinflammationmeta-analysispsoriasis

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