Related Experiment Video
Updated: Aug 17, 2025
Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
Association between high-sensitivity-CRP and liver elastography and cardiac ischemic diseases in patients with fatty
Morteza Nayebi1, Seyed Saeed Seyedian1, Seyed Jalal Hashemi1
1Department of Gastroenterology, Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Insights
High-sensitivity C-reactive protein (hs-CRP) is linked to fatty liver and cardiac ischemia. Elevated hs-CRP levels in fatty liver patients may predict cardiac ischemia risk.
Area of Science:
- Cardiology
- Hepatology
- Biomarkers
Background:
- Inflammatory markers are implicated in hepatic and ischemic heart disease.
- Fatty liver disease is increasingly recognized as a systemic condition.
- The role of specific inflammatory markers in linking fatty liver to cardiac issues requires further elucidation.
Purpose of the Study:
- To investigate the association between high-sensitivity C-reactive protein (hs-CRP), liver elastography, and cardiac ischemic diseases.
- To determine if hs-CRP can serve as a predictive marker for cardiac ischemia in patients with fatty liver.
Main Methods:
- A cross-sectional comparative study involving 103 consecutive patients diagnosed with fatty liver.
- Patients underwent angiography and were categorized into groups with and without cardiac ischemia.
- hs-CRP levels and liver elastography were assessed.
Main Results:
- Mean hs-CRP levels were significantly higher in patients with cardiac ischemia (10.9 mg/L) compared to those without (2.3 mg/L) (P=0.001).
- Receiver operating characteristic (ROC) analysis indicated a predictive role for hs-CRP with 94.5% accuracy.
- hs-CRP demonstrated high sensitivity (95.2%) and specificity (90%) with a cut-off point of 3.1 mg/L for predicting cardiac ischemia.
Conclusions:
- An association exists between fatty liver, cardiac ischemia, and hs-CRP levels.
- hs-CRP may serve as a valuable non-invasive biomarker for assessing cardiac ischemia risk in patients with fatty liver.
- Further research is warranted to explore the underlying mechanisms linking these conditions.
Objective:
Inflammatory markers are among the possible contributing factors with a proposed role in hepatic and ischemic heart disease. The present study aimed to determine the association between high-sensitivity-C-reactive protein (hs-CRP), liver elastography, and cardiac ischemic diseases in patients with fatty liver.
Methods:
In this cross-sectional comparative study, 103 consecutive patients with fatty liver were enrolled to undergo angiography. They were divided into groups with and without cardiac ischemia.
Results:
The results demonstrated that the mean hs-CRP was 2.3 and 10.9 mg/L in normal and ischemic angiography groups, respectively (P = 0.001). According to the receiver operating characteristic (ROC) analysis, the predictive role for hs-CRP was 94.5% that had sensitivity and specificity of 95.2% and 90%, respectively, with a cut-off point of 3.1.
Conclusion:
This study showed that there is an association between the fatty liver, cardiac ischemia, and hs-CRP level.
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:20Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:21Imaging Studies for Cardiovascular System IV: CMRI