Related Experiment Video

Updated: Aug 17, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.0K

Emerging roles of alternative RNA splicing in oral squamous cell carcinoma

Miaomiao Liu1, Jihua Guo1,2, Rong Jia1,3

  • 1The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Frontiers in Oncology
|December 12, 2022
PubMed

Insights

Alternative RNA splicing (ARS) alterations drive oral cancer. Dysregulated splicing factors and ARS events in oral squamous cell carcinoma (OSCC) offer diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Alternative RNA splicing (ARS) is a crucial post-transcriptional regulatory mechanism.
  • ARS generates diverse protein isoforms from a single gene, impacting cellular functions.
  • Dysregulation of ARS is implicated in various cancers, including oral squamous cell carcinoma (OSCC).

Purpose of the Study:

  • To review the expression and roles of splicing factors in OSCC.
  • To examine alternative RNA splicing events associated with OSCC development.
  • To discuss recent therapeutic strategies targeting ARS in OSCC.

Main Methods:

  • Literature review of studies on ARS, splicing factors, and OSCC.
  • Analysis of the impact of splicing factor dysregulation on OSCC tumorigenesis.
  • Synthesis of current knowledge on ARS-related biomarkers and therapeutic targets in OSCC.

Main Results:

  • Splicing factors are frequently dysregulated in OSCC and contribute to cancer progression.
  • Specific ARS events are characteristic of OSCC and can serve as diagnostic/prognostic indicators.
  • Targeting ARS pathways presents a promising therapeutic avenue for OSCC.

Conclusions:

  • ARS dysregulation and altered splicing factor expression are key events in OSCC.
  • ARS-based biomarkers hold potential for OSCC diagnosis and prognosis.
  • Targeting ARS offers a novel therapeutic strategy for oral cancer treatment.
Keywords:
OSCCalternative splicingsplicing factortherapeutic targetstumor progression

More Related Videos

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.0K
Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

13.8K

Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.6K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.6K
Pre-mRNA Processing: RNA Splicing01:36

Pre-mRNA Processing: RNA Splicing

5.3K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
7.1K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.3K
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

2.8K