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Updated: Aug 17, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
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Obstetric Sepsis: A Review Article.

Arun Harishchandra Nayak1, Shweta Avinash Khade1

  • 1Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra 400022 India.

Journal of Obstetrics and Gynaecology of India
|December 12, 2022
PubMed
Summary
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Obstetric (maternal) sepsis, a severe organ failure from infection during pregnancy or postpartum, is a leading cause of maternal death globally. Early diagnosis and management are crucial for reducing maternal mortality.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Obstetric (maternal) sepsis is defined by the World Health Organization as organ failure resulting from infection during pregnancy, childbirth, post-abortion, or postpartum periods.
  • It represents the third leading cause of maternal mortality, accounting for 11% of all maternal deaths worldwide.
  • Pregnancy-related physiological changes can mimic sepsis symptoms, complicating accurate diagnosis.

Purpose of the Study:

  • To highlight the significance of obstetric sepsis as a critical cause of maternal mortality.
  • To underscore the challenges in diagnosing sepsis during pregnancy.
  • To emphasize the need for improved strategies in managing maternal sepsis.

Main Methods:

  • Review of World Health Organization definitions and global statistics on maternal mortality.
Keywords:
MaternalMorbidityMortalityObstetric sepsisPregnancyPuerperiumSeptic shock

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  • Analysis of diagnostic challenges posed by physiological changes during pregnancy.
  • Examination of existing diagnostic tools and criteria for sepsis.

    • Main Results:

    • Obstetric sepsis is a major contributor to preventable maternal deaths globally.
    • Diagnostic difficulties arise from overlapping symptoms between sepsis and normal pregnancy changes.
    • A range of diagnostic tools and criteria exist but require careful application.

    Conclusions:

    • Effective prevention, early detection, and prompt treatment of obstetric sepsis are vital to decrease maternal mortality and morbidity.
    • Future policy development focusing on the evaluation and care of obstetric sepsis is essential to reduce unnecessary maternal deaths.