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Janus kinases inhibitors for coronavirus disease-2019: A pairwise and Bayesian network meta-analysis

Jianyi Niu1,2, Zhiwei Lin1,2, Zhenfeng He1,2

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Frontiers in Medicine
|December 12, 2022
PubMed
Abstract

Insights

Janus kinase (JAK) inhibitors effectively reduce mortality in COVID-19 patients without increasing adverse events. Ruxolitinib shows the greatest potential benefit for both mortality and safety outcomes among JAK inhibitors.

Area of Science:

  • Immunology
  • Pharmacology
  • Infectious Diseases

Background:

  • Janus kinase (JAK) inhibitors are being investigated as a potential treatment for coronavirus disease-2019 (COVID-19).
  • The precise benefits and optimal use of JAK inhibitors for COVID-19 remain unclear.

Conclusions:

  • Janus kinase (JAK) inhibitors represent a promising therapeutic option for reducing mortality in COVID-19 patients compared to standard care.
  • The safety profile of JAK inhibitors is favorable, with no increased risk of adverse events.
  • Ruxolitinib emerges as a potentially superior JAK inhibitor, offering the greatest likelihood of benefits in terms of both mortality reduction and adverse event management in COVID-19.
Keywords:
COVID-19JAK inhibitorsadverse eventsmortalitynetwork meta-analysis

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