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Updated: Aug 17, 2025
Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species
Published on: October 15, 2013
Activity of ETX0462 toward Some Burkholderia spp
Elise T Zeiser1, Scott A Becka1, John J LiPuma2
1Research Service, VA Northeast Healthcare System, Cleveland, Ohio, USA.
Abstract:
Burkholderia cepacia complex (Bcc) and Burkholderia gladioli are opportunistic human pathogens that are inherently multidrug resistant, limiting treatment options for infections. Here, a novel diazabicyclooctane, ETX0462, was evaluated for activity against Bcc and B. gladioli. Ninety-eight percent of the isolates examined in this study were susceptible. ETX0462 was found to demonstrate in vitro activity superior to that of currently available treatment options (e.g., trimethoprim-sulfamethoxazole and ceftazidime).
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