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Updated: Aug 17, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers.

Amrita K Cheema^1,2, Yaoxiang Li¹, Mary Ventimiglia¹

¹Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

|December 12, 2022

Summary

This summary is machine-generated.

Radiotherapy stimulates the innate immune response (IIR) in cancer patients, with distinct molecular profiles observed in those achieving remission versus those experiencing disease progression. This immune activation may inform future cancer treatment strategies.

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Area of Science:

Oncology
Immunology
Molecular Biology

Background:

Radiotherapy is a cornerstone cancer treatment, often combined with surgery or chemotherapy.
Advanced techniques allow precise radiation delivery to damage cancer cell DNA and stimulate an innate immune response (IIR).

Purpose of the Study:

To investigate systemic molecular changes following prostate stereotactic body radiotherapy.
To correlate proteomic and metabolomic alterations with clinical outcomes in cancer patients.

Main Methods:

Plasma proteomic and metabolomic analyses were conducted at intervals post-radiotherapy.
Pathway and multivariate analyses were employed to identify molecular changes and their clinical correlations.

Main Results:

DNA damage response peaked within 1 hour and normalized by 1 month.
Innate immune response (IIR) signaling increased early and persisted for up to 3 months.
Remission patients showed robust IIR and M1-associated metabolites; progressing patients had weaker responses and M2 metabolites.

Conclusions:

This study presents the first longitudinal proteomic and metabolomic analysis of patients post-radiotherapy.
Innate immune activation is a key clinical response to radiotherapy in prostate cancer.
Findings suggest IIR modulation could be a therapeutic strategy for various cancer types.