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Updated: Aug 17, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Catalytic enantioselective desymmetrization of meso-aziridines
Pei-Jun Yang1,2, Zhuo Chai2
1Anhui Province Key Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Middle Beijing Road, Wuhu, Anhui 241000, China.
Abstract:
As a type of readily available small strained-ring heterocycle, meso-aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of meso aziridines and highlights some promising avenues for further work in this realm.
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