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Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Corneal Ulcer due to Monkeypox Infection.

David Lamas-Francis¹, Mercedes Treviño², Hugo Pérez-Freixo³

¹Ophthalmology, University Hospital of Santiago de Compostela, Santiago, Spain.

Ocular Immunology and Inflammation

|December 12, 2022

Summary

This case report details a rare instance of monkeypox virus causing epithelial keratitis. PCR confirmed monkeypox DNA in the cornea, highlighting a new ocular manifestation of the virus.

Keywords:

Corneal ulcer infectious keratitis keratitis monkeypox

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Area of Science:

Ophthalmology
Infectious Diseases
Virology

Background:

Monkeypox virus (MPXV) primarily causes mucocutaneous lesions.
Ocular manifestations of MPXV are uncommon, with previous reports focusing on blepharitis and conjunctivitis.

Observation:

A 45-year-old male developed epithelial keratitis with a corneal ulcer 20 days after MPXV diagnosis.
Polymerase chain reaction (PCR) analysis of corneal epithelium confirmed the presence of human monkeypox virus DNA.

Findings:

The patient received ganciclovir gel, povidone iodine, moxifloxacin eye drops, and oral tecovirimat.
A therapeutic contact lens was used, and the corneal defect healed within 20 days, leaving minimal subepithelial haze and good visual acuity (0.8).

Implications:

This case confirms MPXV can cause epithelial keratitis, an uncommon but significant ocular complication.
Early diagnosis and appropriate antiviral treatment are crucial for managing MPXV-related ocular disease.
Further research is needed to understand the pathogenesis and long-term visual outcomes of MPXV keratitis.