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CMV Retinitis with Panretinal Occlusive Vasculitis.

I Wang¹, Benjamin Chi-Lan Yang¹, Kun-Hsien Li²

¹Department of Ophthalmology, Eye Center, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Ocular Immunology and Inflammation

|December 12, 2022

Summary

This summary is machine-generated.

Cytomegalovirus (CMV) retinitis with panretinal occlusive vasculitis shows slow lesion resolution, making rapid improvement an unreliable indicator of treatment effectiveness. Vascular occlusion can worsen despite antiviral therapy, impacting macular function.

Keywords:

CMV retinitis Chronic CMV retinitis cytomegalovirus retinitis immunocompromised patients panretinal occlusive vasculitis

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Area of Science:

Ophthalmology
Infectious Diseases
Virology

Background:

Cytomegalovirus (CMV) retinitis is a serious ocular infection.
Panretinal occlusive vasculitis is a severe manifestation of CMV retinitis.
Understanding treatment efficacy in non-HIV patients is crucial.

Purpose of the Study:

To describe the clinical characteristics of cytomegalovirus retinitis accompanied by panretinal occlusive vasculitis.
To evaluate the therapeutic response and visual outcomes in such cases.

Main Methods:

Retrospective case series design.
Inclusion of four eyes from three non-human immunodeficiency virus (HIV) patients.
Treatment with oral valganciclovir and intravitreal ganciclovir.

Main Results:

All four eyes exhibited slow resolution of retinitis-related retinal opacification.
Two eyes showed persistent opacification even after discontinuation of antiviral agents, with slow resolution over months.
Final visual acuity was 0.02 or worse in three of the four eyes.

Conclusions:

Rapid resolution of retinitis lesions is an unreliable indicator of therapeutic efficacy in CMV retinitis with panretinal occlusive vasculitis.
Deteriorating vascular occlusion can occur despite antiviral treatment, posing a risk to macular function.