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Related Experiment Video

Updated: Aug 17, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

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Published on: April 18, 2019

PFAS levels and exposure determinants in sensitive population groups.

L Fábelová¹, A Beneito², M Casas³

¹Slovak Medical University in Bratislava, Faculty of Public Health, Department of Environmental Medicine, Bratislava, Slovakia.

|December 12, 2022

Summary

This summary is machine-generated.

Per- and polyfluoroalkyl substances (PFAS) are widespread. Maternal age, education, and diet influence PFAS levels in pregnant women and newborns, with dairy intake linked to lower concentrations. This highlights key factors for reducing exposure.

Keywords:

Cord blood Determinants F ood consumption Maternal blood per- and polyfluoroalkyl substances

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Area of Science:

Environmental Health
Toxicology
Reproductive Health

Background:

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants with ubiquitous exposure starting in utero.
Exposure continues postnatally through breast milk, diet, environment, and consumer products.

Purpose of the Study:

To identify determinants of PFAS concentrations in sensitive populations: pregnant women and newborns.
To investigate associations between maternal characteristics, parental education, and PFAS levels.

Main Methods:

Analysis of PFAS (PFOS, PFOA, PFHxS, PFNA) in maternal or cord blood from nine European birth cohorts (N=6837).
Evaluation of maternal factors (age, BMI, parity, breastfeeding, smoking, diet) and parental education using multiple linear regression.

Main Results:

Higher PFAS concentrations correlated with increased maternal age, primiparity, and higher educational levels.
Maternal PFAS levels linked to higher intake of fish, seafood, meat, offal, and eggs; cord blood PFAS associated with meat and offal consumption.
Daily consumption of milk and dairy products was associated with lower PFAS concentrations in both mothers and newborns.

Conclusions:

Ubiquitous PFAS exposure in pregnant women and newborns is confirmed by high detection rates.
Dietary factors, maternal characteristics, and education are significant determinants of PFAS exposure.
Findings provide a basis for developing strategies to reduce PFAS exposure, particularly via dietary modifications.