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Updated: Aug 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Mechanical DNA Origami to Investigate Biological Systems.

Allan Mills¹, Nesrine Aissaoui², Julie Finkel¹

¹Centre de Biologie Structurale, INSERM, CNRS, Université de Montpellier, Montpellier, 34090, France.

Advanced Biology

|December 12, 2022

Summary

This summary is machine-generated.

This review explores DNA nanodevices capable of sensing and responding to their environment. These dynamic nanomachines offer potential for precise molecular force measurements in nanomedicine and mechanobiology.

Keywords:

DNA nanotechnology DNA origami mechanobiology

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Last Updated: Aug 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Production of Dynein and Kinesin Motor Ensembles on DNA Origami Nanostructures for Single Molecule Observation

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Published on: October 15, 2019

Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

Responsive biomolecular function relies on conformational changes influenced by environmental interactions.
DNA nanodevices offer programmable structural dynamics for sensing and responding to local environments.
Applications span mechanobiology and nanomedicine, leveraging molecular-scale force measurement.

Purpose of the Study:

To review the state-of-the-art in constructing dynamic DNA nanodevices for molecular force measurement.
To highlight the engineering of modular DNA devices for cell surface interactions.
To discuss challenges and future outlook for DNA nanomachines in biological applications.

Main Methods:

Summarizing current techniques for creating complex DNA geometries with dynamic and mechanical properties.
Reviewing the design of modular DNA devices for interacting with cell surfaces.
Analyzing examples of mechanosensitive proteins and force-induced signaling.

Main Results:

DNA nanodevices can be engineered for precise molecular-scale force measurements.
Modular DNA devices can interact with cell surfaces, influencing biochemical signaling.
These nanodevices function as nanomachines operating in the piconewton range.

Conclusions:

DNA nanodevices represent a promising platform for mechanobiology and nanomedicine.
Further development is needed for applications requiring low piconewton forces or higher tension exertion.
Hybrid materials incorporating DNA nanodevices can achieve diverse mechanical requirements.