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Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
Published on: July 16, 2018
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Establishment of a meta-analysis based novel aortic dissection mouse model
Hongcheng Jiang1,2, Wanjun Liu1,2, Xingwei He3,4
1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Scientific Reports
|December 12, 2022
Summary
This study establishes a reliable mouse model for aortic dissection (AD) using β-aminopropionitrile and angiotensin II. The findings highlight optimal conditions for inducing AD in animal research, aiding further mechanistic studies.
Area of Science:
- Cardiovascular Research
- Animal Models
- Pathogenesis Studies
Background:
- Aortic dissection (AD) is a critical condition with unclear mechanisms.
- Effective animal models are essential for understanding AD pathogenesis.
- Existing models may lack reliability, cost-effectiveness, or time efficiency.
Conclusions:
- A reliable mouse model for aortic dissection is established using BAPN and AngII in ApoE-/- mice.
- The optimal protocol involves 1 g/L BAPN for 3 weeks followed by 2500 ng/kg/min AngII infusion for 2 weeks.
- This model provides a robust platform for investigating AD mechanisms and therapeutic strategies.
