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Updated: Aug 17, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

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Published on: February 21, 2025

Irisin ameliorates age-associated sarcopenia and metabolic dysfunction.

Mingwei Guo¹, Jing Yao¹, Jin Li²

¹Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.

Journal of Cachexia, Sarcopenia and Muscle

|December 12, 2022

Summary

Reduced levels of fibronectin type III domain-containing protein 5 (FNDC5), also known as irisin, contribute to age-associated sarcopenia and metabolic dysfunction. Irisin administration can ameliorate these age-related declines in muscle and metabolic health.

Keywords:

FNDC5 ageing irisin metabolic dysfunction sarcopenia

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Published on: April 22, 2022

Area of Science:

Gerontology
Molecular Biology
Metabolic Physiology

Background:

Age-associated sarcopenia involves progressive loss of skeletal muscle mass, strength, and function.
Aging is frequently accompanied by metabolic dysfunctions, impacting overall health.
Irisin, a myokine derived from FNDC5, is linked to exercise-induced health benefits.

Purpose of the Study:

To investigate changes in FNDC5/irisin expression in skeletal muscle during aging.
To determine if irisin administration can counteract age-related sarcopenia and metabolic decline.

Main Methods:

Quantitative real-time PCR and western blotting analyzed FNDC5/irisin levels in young and aged mice.
FNDC5/irisin knockout mice were used to assess the impact of its deficiency on aging.
Recombinant irisin was administered to aging mice to evaluate therapeutic effects on sarcopenia and metabolic parameters.

Main Results:

FNDC5/irisin expression decreased in aged mice, and its deficiency exacerbated muscle atrophy and molecular changes.
Irisin treatment improved muscle strength, mass, fiber size, and molecular phenotypes in aging mice.
Irisin administration alleviated age-associated fat tissue expansion, insulin resistance, and hepatic steatosis.

Conclusions:

Irisin plays a crucial role in maintaining muscle physiology and systemic energy homeostasis during aging.
Irisin administration presents a potential therapeutic strategy for combating age-related sarcopenia and metabolic diseases.