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Related Experiment Video

Updated: Aug 17, 2025

Development of a Refined Protocol for Trans-scleral Subretinal Transplantation of Human Retinal Pigment Epithelial Cells into Rat Eyes
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Robot-assisted subretinal injection system: development and preliminary verification.

Kunkun Yang1,2, Xin Jin2, Zhaodong Wang3

  • 1Graduate School of Chinese PLA General Hospital, 100853, Beijing, China.

BMC Ophthalmology
|December 12, 2022
PubMed
Summary

A new robot-assisted subretinal injection system (RASR) demonstrates superior stability in subretinal injection procedures. This surgical robot significantly reduces tremor compared to manual methods, enhancing surgical precision.

Keywords:
Medical robotOphthalmic robotRobot-assisted surgerySubretinal injection

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Area of Science:

  • Ophthalmology
  • Robotics in Surgery
  • Medical Device Development

Background:

  • Subretinal injections are crucial for treating various retinal diseases.
  • Current manual techniques face challenges in precision and stability.
  • Development of robotic assistance aims to overcome these limitations.

Purpose of the Study:

  • To design and develop a surgical robot for subretinal injection assistance.
  • To evaluate the performance and stability of the robot-assisted system compared to manual methods.

Main Methods:

  • A robot-assisted subretinal surgery robot (RASR) was developed using remote center of motion (RCM) and master-slave teleoperation.
  • Subretinal injections were performed on porcine eyes in both robot manipulation (RM) and manual manipulation (MM) groups.
  • Performance was assessed using optical coherent tomography (OCT), fundus photography, and video motion capture analysis.

Main Results:

  • Both RM and MM groups achieved 100% success rate for subretinal injections.
  • No significant difference in subretinal area or fluid volume was observed between groups (P > 0.05).
  • Robot manipulation showed a significant reduction in tremor amplitude (0.3681 pixels) compared to manual manipulation (18.8779 pixels) (P < 0.0001).

Conclusions:

  • The robot-assisted subretinal injection system (RASR) is capable of performing subretinal injections.
  • RASR offers significantly improved stability and reduced tremor compared to manual manipulation.
  • The system shows potential for enhancing precision and reducing surgeon fatigue in subretinal surgery.