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Changes in sensory-related brain networks of patients with moyamoya disease with limb paresthesia: A resting-state
Rujing Sun1, Shi-Yu Zhang1, Xu Cheng1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Abstract:
This study's aim was to investigate functional brain connectivity changes among patients with moyamoya disease (MMD) with limb paresthesia, using functional connectivity analysis based on resting-state functional magnetic resonance imaging (rs-fMRI). A total of 181 patients with MMD were enrolled, including 57 with left limb paresthesia (MLP group), 61 with right limb paresthesia (MRP group), and 63 without paresthesia (MWP group). Encephaloduroarteriosynangiosis (EDAS) was performed in 20 of the 57 patients with left limb paresthesia and 15 of the 61 patients with right limb paresthesia. Twenty-nine age- and sex-matched healthy controls (HC group) were recruited during the same period. All participants underwent rs-fMRI examination, and the patients treated with EDAS were re-examined 3-4 months after the surgery. After data preprocessing, we selected Brodmann area 3 on each side of the brain as the seed region to construct a functional connectivity network of the whole brain, and then we analyzed the differences in functional connectivity between the HC group, MWP group, MLP group, and MRP group. The functional connectivity of Brodmann area 3 (on either side) with the ipsilateral frontal (superior frontal gyrus, middle frontal gyrus, and inferior frontal gyrus) and parietal (supramarginal gyrus, angular gyrus, and superior parietal lobule) cortices was increased among patients with MMD. The functional connectivity enhancement in these brain regions was broader and greater in patients with contralateral limb paresthesia than in patients without paresthesia, and the regions with functional connectivity changes were roughly distributed symmetrically among the MLP group and the MRP group. There were no changes 3-4 months after EDAS in the increased functional connectivity between the frontal and parietal cortices and Brodmann area 3. Limb paresthesia in patients with MMD may be driven by abnormal functional connectivity in the frontal and parietal cortices. Functional changes in associated brain regions may be a target for evaluating the severity of MMD and its response to treatment.
Insights
Moyamoya disease (MMD) patients with limb paresthesia show increased functional brain connectivity in frontal and parietal areas. These changes, linked to paresthesia, may help assess MMD severity and treatment response.
Area of Science:
- Neuroscience
- Neurology
- Radiology
Background:
- Moyamoya disease (MMD) is a rare cerebrovascular disorder.
- Limb paresthesia is a common symptom in MMD patients.
- Understanding the neural basis of paresthesia in MMD is crucial for patient management.
Purpose of the Study:
- To investigate functional brain connectivity alterations in MMD patients with limb paresthesia.
- To compare connectivity patterns between MMD patients with and without paresthesia, and healthy controls.
- To explore the impact of Encephaloduroarteriosynangiosis (EDAS) on functional connectivity.
Main Methods:
- Resting-state functional magnetic resonance imaging (rs-fMRI) was used to assess functional brain connectivity.
- 181 MMD patients (with/without limb paresthesia) and 29 healthy controls were included.
- Functional connectivity analysis focused on Brodmann area 3 as the seed region.
Main Results:
- MMD patients exhibited increased functional connectivity between Brodmann area 3 and ipsilateral frontal/parietal cortices.
- This connectivity enhancement was more pronounced in patients with limb paresthesia.
- No significant changes in connectivity were observed 3-4 months post-EDAS surgery.
Conclusions:
- Abnormal functional connectivity in frontal and parietal cortices may drive limb paresthesia in MMD.
- Altered brain connectivity patterns could serve as biomarkers for MMD severity and treatment efficacy.
- Further research is needed to elucidate the precise mechanisms underlying these functional changes.
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