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Related Experiment Video

Updated: Jun 27, 2026

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

Low-Level Light Therapy in Association with Intense Pulsed Light for Meibomian Gland Dysfunction.

João Heitor Marques¹, Ana Marta^1,2, Pedro Manuel Baptista^1,2

¹Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Clinical Ophthalmology (Auckland, N.Z.)

|December 13, 2022

Summary

Intense pulsed light effectively treats meibomian gland dysfunction. Low-level light therapy shows weak evidence of improving tear production, but offers no significant additional benefit when combined with intense pulsed light.

Keywords:

dry eye syndromes intense pulsed light therapy low-level light therapy meibomian gland dysfunction phototherapy

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Induction of Ocular Surface Inflammation and Collection of Involved Tissues

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Published on: August 4, 2022

Area of Science:

Ophthalmology
Dermatology
Biomedical Engineering

Background:

Meibomian gland dysfunction (MGD) is a common cause of evaporative dry eye disease.
Current treatments for MGD aim to improve meibomian gland function and ocular surface health.

Purpose of the Study:

To evaluate the clinical benefit of adding low-level light therapy (LLLT) to intense pulsed light (IPL) for MGD treatment.
To compare the efficacy of IPL alone versus IPL combined with LLLT in improving MGD symptoms and signs.

Main Methods:

An observational study involving two groups of MGD patients.
Group 1 received IPL followed by LLLT; Group 2 received IPL alone.
Treatments consisted of 3 sessions, with evaluations at baseline and 3 weeks post-treatment.

Main Results:

Both treatment groups showed significant improvements in Ocular Surface Disease Index (OSDI) scores and lipid layer thickness.
Group 1 (IPL + LLLT) demonstrated a statistically significant improvement in the Schirmer test, indicating increased tear production.
No significant side effects were reported in either group.

Conclusions:

Intense pulsed light is effective and safe for treating MGD, improving symptoms and lipid layer thickness.
Low-level light therapy, when added to IPL, shows weak evidence of enhancing aqueous tear production but no strong additional clinical benefit for MGD.
Further research may be warranted to elucidate the specific role of LLLT in MGD management.