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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Role of sonic hedgehog ligand in gastric cancer therapeutics

Kulsum Akhtar1, Irfan Maqbool1, Gulzar Ahmad Bhat1

  • 1Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Journal of Cancer Research and Therapeutics
|December 13, 2022
PubMed
Abstract

Insights

Sonic hedgehog (SHH) signaling pathway is abnormally activated in gastric cancer (GC). SHH is overexpressed in GC tissues, suggesting its potential as a biomarker and therapeutic target for gastric cancer progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • The sonic hedgehog (SHH) signaling pathway plays a critical role in embryonic development and is implicated in the progression of various cancers, including Gastric Cancer (GC).
  • Aberrant SHH pathway activation is linked to the development and advancement of GC, highlighting its significance in gastric tumorigenesis.

Purpose of the Study:

  • To investigate the messenger RNA (mRNA) and protein expression levels of SHH in gastric cancer tissues.
  • To explore the correlation between SHH expression and clinicopathological parameters in patients with GC.

Main Methods:

  • Analysis of SHH mRNA and protein expression in 53 surgically resected GC tumors and adjacent normal tissues.
  • Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) were employed for expression analysis.

Main Results:

  • SHH mRNA was overexpressed in 60% of GC cases compared to normal tissues.
  • SHH protein overexpression was observed in 43.39% of GC tissues, with abundant cytoplasmic localization.
  • No significant association was found between SHH overexpression and clinicopathological parameters.

Conclusions:

  • SHH is dysregulated in gastric cancer, indicating its potential role in GC progression.
  • SHH may serve as a valuable biomarker for gastric cancer.
  • Targeting the SHH pathway presents a potential therapeutic strategy for gastric cancer treatment.
Keywords:
Gastric cancerimmunohistochemistryquantitative real-time polymerase chain reactionsonic hedgehog

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