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Osteoprotegerin and Ischemic Stroke Prognosis: A Prospective Multicenter Study and Mendelian Randomization Analysis
Zhengbao Zhu1,2, Daoxia Guo1, Kaixin Zhang1
1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou Medical College of Soochow University, China (Z.Z., D.G., K.Z., P.Y., Y.J., M.S., A.W., T.X., Y.Z.).
Elevated osteoprotegerin levels indicate a poorer prognosis for ischemic stroke patients. This finding was supported by Mendelian randomization analysis, suggesting a causal link between high osteoprotegerin and increased stroke risk.
Area of Science:
- Cardiovascular Research
- Biomarkers
- Stroke Medicine
Background:
- Osteoprotegerin (OPG) is linked to vascular injury and inflammation.
- Its prognostic role in ischemic stroke has not been fully elucidated.
Purpose of the Study:
- To prospectively investigate the association between plasma OPG levels and ischemic stroke prognosis.
- To combine observational data with Mendelian randomization analysis.
Main Methods:
- Prospective cohort study of 3490 ischemic stroke patients.
- Measurement of baseline plasma OPG levels.
- Follow-up for death and major disability at 3 months.
- Mendelian randomization analysis to assess causality.
Main Results:
- Elevated OPG levels were associated with increased risks of death and major disability post-stroke.
- Each 1-SD increase in log-OPG correlated with a 18% higher risk of the primary outcome.
- Genetically determined high OPG was linked to an increased risk of the primary outcome in Mendelian randomization.
Conclusions:
- Plasma OPG is a significant prognostic marker for poor outcomes in ischemic stroke.
- Genetic predisposition to high OPG may causally increase ischemic stroke risk.
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