The Role of Exercise-Induced Reactive Oxygen Species (ROS) Hormesis in Aging: Friend or Foe
Ronny Lesmana1,2,3, Cynthia Parameswari4, Gabriela Fernanda Mandagi4
1Physiology Division, Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia, ronny@unpad.ac.id.
Summary
Regular exercise, particularly continuous activity, helps manage reactive oxygen species (ROS) and may delay aging. Certain nutraceuticals like creatine, whey, and ascorbic acid can enhance exercise benefits for an improved quality of life.
Area of Science:
- Biochemistry
- Exercise Physiology
- Gerontology
Background:
- Reactive oxygen species (ROS) are implicated in aging, inflammation, and neurodegenerative diseases.
- Aging is associated with increased cellular senescence and reduced endogenous antioxidant capacity.
- Exercise is a known modulator of ROS, with effects varying based on type and intensity.
Approach:
- This review synthesizes studies examining exercise's role in regulating ROS production and enhancing antioxidant defenses.
- Investigates how different exercise modalities influence ROS levels and cellular aging.
- Evaluates the synergistic effects of nutraceutical antioxidants with exercise interventions.
Key Points:
- Long-term exercise potentiates antioxidant systems and modulates ROS production pathways.
- Specific exercise types induce distinct ROS profiles, impacting cellular aging differently.
- Nutraceuticals such as creatine, whey, and ascorbic acid may amplify exercise-induced anti-aging benefits.
Conclusions:
- Continuous, well-chosen exercise regimens are beneficial for the aging population, improving quality of life.
- Exercise interventions should consider the type and continuity to optimize ROS regulation and anti-aging effects.
- Combining exercise with specific nutraceuticals shows promise for enhanced healthspan and mitigating age-related decline.
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