Related Experiment Video
Updated: May 3, 2026
Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Daiyong Chao1,2, Qing Dong1,2, Zhixuan Yu2,3
1College of Chemistry, Jilin University, Changchun, Jilin 130012, China.
Abstract:
Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress microenvironment in diabetic chronic wounds, which leads to a natural transition from the inflammation phase to the proliferation phase. Impressively, the efficacy of one-time-applied MOF/Gel was comparable to that of the human epidermal growth factor Gel, a widely used clinical drug for various wound treatments. Such an effective, safe, and convenient MOF/Gel system can meet complex clinical demands.
Insights
This study introduces MOF/Gel, an antioxidative system that effectively heals diabetic chronic wounds by scavenging reactive oxygen species. Its performance is comparable to clinical treatments, offering a promising solution for diabetic wound care.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Diabetic chronic wounds present a significant clinical challenge due to prolonged inflammation and unsatisfactory treatments.
- The key difference in diabetic wounds is an extended, ineffective inflammation phase.
- Oxidative stress exacerbates the healing impairment in diabetic chronic wounds.
Purpose of the Study:
- To develop and evaluate an effective antioxidative system for promoting diabetic chronic wound healing.
- To investigate the potential of a metal-organic framework (MOF) nanozyme integrated into a hydrogel (Gel) for wound treatment.
- To address the limitations of current therapies for diabetic wound complications.
Main Methods:
- Integration of a metal-organic framework (MOF) nanozyme with antioxidant properties into a hydrogel (Gel) to create MOF/Gel.
- Application of MOF/Gel to diabetic chronic wounds in a rat model.
- Assessment of the system's ability to scavenge reactive oxygen species (ROS) and modulate the wound microenvironment.
- Comparison of MOF/Gel efficacy with a clinically used human epidermal growth factor gel.
Main Results:
- MOF/Gel effectively scavenged reactive oxygen species, mitigating oxidative stress in the wound microenvironment.
- The system facilitated a natural transition from the inflammation phase to the proliferation phase of wound healing.
- A single application of MOF/Gel demonstrated efficacy comparable to human epidermal growth factor gel.
- The MOF/Gel system proved safe and convenient for wound treatment.
Conclusions:
- The developed MOF/Gel system offers an effective strategy for treating diabetic chronic wounds.
- This antioxidative system successfully modulates the wound microenvironment, promoting accelerated healing.
- MOF/Gel presents a promising, safe, and convenient alternative to existing clinical treatments for diabetic wound complications.
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