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Related Experiment Video

Updated: Aug 17, 2025

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

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Structural Color Ionic Hydrogel Patches for Wound Management.

Yu Wang¹, Lingyu Sun¹, Guopu Chen¹

¹Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing210096, China.

|December 13, 2022

Summary

This study introduces intelligent wound care patches made from a novel ionic hydrogel. These advanced patches offer accurate wound monitoring and promote healing, showcasing potential for clinical use.

Keywords:

bioinspired ionic hydrogel patch structural color wound healing

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Area of Science:

Biomaterials Science
Polymer Chemistry
Regenerative Medicine

Background:

Ionic hydrogels are crucial for electronic skins and biosensors.
Developing hydrogels with enhanced detection and multifunctionality is an ongoing challenge.
Intelligent wound management requires advanced materials for monitoring and healing.

Purpose of the Study:

To develop a structural color ionic hydrogel patch for intelligent wound management.
To create a composite patch with a conductive, freeze-resistant scaffold and a healing-promoting surface.
To evaluate the patch's efficacy for in vivo wound healing and monitoring.

Main Methods:

Fabrication of an inverse opal scaffold using polyacrylamide-poly(vinyl alcohol)-polyethylenimine-lithium chloride (PAM-PVA-PEI-LiCl).
Incorporation of vascular endothelial growth factor (VEGF) into a methacrylated gelatin (GelMA) hydrogel filler surface.
Characterization of the composite patch's structural color, conductivity, and freeze resistance.
Assessment of the patch's performance in preventing wound interference and promoting cell proliferation.

Main Results:

The composite patches exhibited brilliant structural color, electrical conductivity, and freezing resistance.
The VEGF-GelMA surface effectively shielded the ionic hydrogel from complex wound environments.
The patches demonstrated significant contributions to cell proliferation and tissue repair in wounds.
The hydrogel patches functioned as electronic skins for accurate in vivo wound healing and monitoring.

Conclusions:

The developed structural color ionic hydrogel patches are suitable for intelligent wound management.
These patches offer a promising platform for advanced electronic skins in biomedical applications.
The unique combination of features suggests high potential for clinical translation in wound care.