Related Experiment Video
Updated: Aug 17, 2025
08:54
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
Published on: May 8, 2018
14.3K
Stereotactic Radiosurgery for Intraventricular Metastases: A Multicenter Study.
Georgios Mantziaris1, Stylianos Pikis1, Zhiyuan Xu1
1Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA.
Neurosurgery
|December 13, 2022
Summary
Stereotactic radiosurgery (SRS) effectively controls intraventricular metastases (IVMs), showing local control rates similar to parenchymal brain metastases. Careful follow-up is essential for potential hydrocephalus or leptomeningeal spread after SRS treatment for IVMs.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Intraventricular metastases (IVMs) are rare and their optimal management is uncertain.
- Stereotactic radiosurgery (SRS) is a potential treatment modality for IVMs.
Purpose of the Study:
- To evaluate the safety and efficacy of SRS for treating intraventricular metastases.
- To define outcomes including local control, distant progression, and adverse events.
Main Methods:
- Retrospective, multicenter study of 160 patients treated with SRS for 196 IVMs.
- Data collected on SRS-induced adverse events, tumor progression, hydrocephalus, and leptomeningeal spread.
- Analysis of neuroimaging and clinical outcomes.
Main Results:
- Median survival post-SRS was 10 months.
- Local IVM control rates at 12 and 24 months were 91.4% and 86.1%, respectively.
- 61% experienced distant intracranial progression; 8.4% had local IVM progression. 10% developed hydrocephalus, 17.5% leptomeningeal dissemination, and 15% adverse radiation effects.
Conclusions:
- SRS is an effective treatment for IVMs, achieving local control rates comparable to parenchymal brain metastases.
- While hydrocephalus and leptomeningeal spread occur in a minority of patients, they necessitate vigilant follow-up.
- SRS offers a viable therapeutic option for carefully selected patients with IVMs.
