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Polymorphonuclear leukocyte function in psoriasis vulgaris.

C T Pease¹, M Fennell, R C Staughton

¹Department of Rheumatology, Westminster Hospital, London, U.K.

The British Journal of Dermatology

|August 1, 1987

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Polymorphonuclear leukocyte (PMN) function in psoriasis vulgaris appears normal. Studies found no significant differences in PMN migration or response to chemotactic substances between psoriasis patients and controls.

Area of Science:

Immunology
Dermatology
Cell Biology

Background:

Psoriasis vulgaris is a chronic inflammatory skin disease.
Polymorphonuclear leukocytes (PMNs) play a role in inflammation.
The function of PMNs in psoriasis requires further investigation.

Purpose of the Study:

To investigate polymorphonuclear leukocyte (PMN) migration and function in patients with psoriasis vulgaris.
To compare PMN function in psoriasis patients with that of a healthy control group.

Main Methods:

In vitro assessment of PMN migration using the agarose plate method.
Evaluation of PMN response to chemotactic substances: F-Met-Leu-Phe (FMLP) and zymosan activated serum (ZAS).
Comparison of chemokinetic and chemotactic potential of psoriatic serum versus control serum.

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Main Results:

No significant difference was observed in PMN migration between psoriasis patients and the control group.
PMN response to FMLP and ZAS did not differ significantly between the two groups.
Psoriatic serum showed no difference in chemokinetic or chemotactic potential compared to control serum.

Conclusions:

The findings do not support a primary abnormality in polymorphonuclear leukocyte (PMN) function in psoriasis vulgaris.
PMN migration and response to common chemotactic stimuli appear intact in psoriasis patients.
Further research may explore other immune cell functions or inflammatory pathways in psoriasis.