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Related Experiment Video

Updated: Aug 17, 2025

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock
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Protocol for postpartum haemorrhage including massive transfusion.

Ove Karlsson1

  • 1Department of Anaesthesiology and Intensive Care, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Anaesthesiology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Best Practice & Research. Clinical Anaesthesiology
|December 13, 2022
PubMed
Summary
This summary is machine-generated.

Severe postpartum hemorrhage (PPH) requires immediate interventions like aorta compression and surgical care. Prompt management, including tranexamic acid and blood product transfusion, is crucial for controlling bleeding and improving maternal outcomes.

Keywords:
FVIIaFXIIIPPHaorta compressionfibrinogenpostpartum haemorrhagetranexamic acidtransfusionvolatile anaesthesia

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Area of Science:

  • Obstetrics and Gynecology
  • Emergency Medicine
  • Critical Care Medicine

Background:

  • Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality globally.
  • Effective management strategies are essential to reduce associated morbidity and mortality.

Purpose of the Study:

  • To outline a comprehensive management approach for postpartum hemorrhage (PPH).
  • To detail interventions based on bleeding severity, including severe and non-severe PPH.

Main Methods:

  • Aorta compression for severe bleeding.
  • Intravenous access for monitoring and blood sampling.
  • Administration of oxygen and crystalloids.
  • Uterotonic drug selection based on local guidelines.
  • Surgical intervention for ongoing bleeding.
  • Hemostasis care including tranexamic acid, 4:4:1 blood product transfusion, and fibrinogen.
  • Goal-directed therapy for non-severe PPH.
  • Anesthesia modification for uterine atony during general anesthesia.

Main Results:

  • Aorta compression can reduce severe bleeding.
  • Prompt surgical care is indicated for ongoing hemorrhage.
  • Specific interventions like tranexamic acid and blood product ratios are vital for severe PPH.
  • Goal-directed therapy is recommended for less severe cases.
  • Switching to intravenous anesthesia is advised for uterine atony under general anesthesia.

Conclusions:

  • Timely and tailored interventions based on PPH severity are critical for effective management.
  • A multi-faceted approach combining mechanical, pharmacological, and surgical methods improves outcomes.
  • Adherence to established guidelines for uterotonics and anesthesia is important.