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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Related Experiment Video

Updated: Jul 1, 2026

Characterization of Anisotropic Leaky Mode Modulators for Holovideo
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All-optical AZO-based modulator topped with Si metasurfaces.

Sareh Vatani1, Behdad Barahimi1, Mohammad Kazem Moravvej-Farshi2

  • 1Nano Plasmo-Photonic Research Group, Faculty of Electrical and Computer Engineering, Tarbiat Modares University, Tehran, 1411713116, Iran.

Scientific Reports
|December 13, 2022
PubMed
Summary

This study introduces a novel all-optical modulator using Al-doped Zinc Oxide (AZO) and a dielectric metasurface. The device achieves high modulation depth and low loss, paving the way for advanced optical communication systems.

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Area of Science:

  • Photonics and Optical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • All-optical communication systems are crucial for next-generation networks.
  • Existing systems face challenges in efficiency and integration.
  • Novel modulator designs are needed to overcome these limitations.

Purpose of the Study:

  • To numerically investigate a novel all-optical modulator.
  • To achieve high modulation depth and low insertion loss.
  • To explore the use of Al-doped Zinc Oxide (AZO) as a tunable optical element.

Main Methods:

  • Numerical investigation of an all-optical modulator design.
  • Utilizing a layer of Al-doped Zinc Oxide (AZO) as the tunable element.
  • Integrating AZO with a distributed Bragg reflector and a dielectric metasurface for guided-mode resonance.

Main Results:

  • Achieved a high modulation depth of 22 dB.
  • Realized a low insertion loss of 0.32 dB.
  • Demonstrated a significant change in reflection from 1% to 93% with low pump fluence (mJ/cm²).

Conclusions:

  • The proposed AZO-based modulator offers high performance for all-optical communication.
  • The engineered dielectric metasurface enhances modulator functionality.
  • This design contributes to the development of next-generation optical communication systems.