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Challenges and Strategies for Solubility Measurements and Dissolution Method Development for Amorphous Solid

Andre Hermans1, Johanna Milsmann2, Hanlin Li3

  • 1Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey, USA. andre_hermans@merck.com.

The AAPS Journal
|December 13, 2022
PubMed
Summary

Developing amorphous solid dispersions (ASDs) for poorly soluble drugs presents unique dissolution challenges. This review offers recommendations for solubility measurements and quality control dissolution methods for ASDs.

Keywords:
Amorphous solid dispersionsCrystallizationDissolutionSolubility

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