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A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: 'DPP-3'

Ozge Ozden1, Cuma Yesildas2, Mustafa Demir2

  • 1Department of Cardiology, Bahcelievler Memorial Hospital, Istanbul, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|December 14, 2022
PubMed

Insights

Dipeptidyl peptidase 3 (DPP-3) levels are elevated in acute coronary syndrome (ACS) patients and predict left ventricle systolic function. Higher DPP-3 indicates myocardial depression, offering a new biomarker for ACS prognosis.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Dipeptidyl peptidase 3 (DPP-3) is an intracellular enzyme linked to cardiac dysfunction when released into circulation.
  • Elevated DPP-3 is observed in conditions like cardiogenic shock, sepsis, and burns.
  • Limited data exists on DPP-3's role in acute coronary syndrome (ACS).

Purpose of the Study:

  • To investigate the association between DPP-3 levels and ACS.
  • To evaluate DPP-3 as a potential predictor of left ventricle systolic function in ACS patients.

Main Methods:

  • Prospective study including ACS patients (STEMI and non-STEMI) and a control group.
  • Measurement of DPP-3 levels at 24, 48, and 72 hours post-symptom onset.
  • Comparison of DPP-3 levels with left ventricle ejection fraction (LVEF) and other biomarkers.

Main Results:

  • ACS patients exhibited significantly higher DPP-3 levels compared to controls.
  • DPP-3 levels were found to be significantly elevated in ACS patients.
  • DPP-3 emerged as an independent predictor of LVEF, comparable to NT-proBNP and troponin I.

Conclusions:

  • DPP-3 may serve as a valuable indicator of myocardial depression in ACS.
  • DPP-3 has the potential to predict left ventricle systolic function in patients with ACS.
Abstract

Keywords:
DPP-3acute coronary syndromeleft ventricle systolic function

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