Engineering microbes to overproduce natural products as agrochemicals

Current agricultural practices heavily rely on the excessive application of synthetic pesticides and fertilizers to meet the food demands of the increasing global population. This practice has several drawbacks including its negative impact on the environment and human health. Recently, the use of natural products has gained interest as alternatives to these synthetic agrochemicals due to their selective working mechanisms and biodegradability. In order to efficiently produce these natural agrochemicals, engineering microorganisms is emerging as an increasingly viable approach, and it is anticipated that it will have a significant market share in the near future. This approach manipulates the metabolism of microbes to manufacture the desired natural compounds from low-cost starting materials. This review discusses recent examples of this approach. The produced natural products can serve as biopesticides or plant growth regulators for the sustainable improvement of plant growth and disease control. The challenges in further developing these strategies are also discussed.