Related Experiment Video
Updated: Aug 17, 2025
Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
Published on: May 17, 2024
Effects of diabetes between generations on the pre-embryos of rats
Vinícius S Barco1, Franciane Q Gallego1, Verônyca G Paula1
1Programa de Pós-Graduação em Tocoginecologia, Universidade Estadual Paulista (UNESP), Faculdade de Medicina de Botucatu, Laboratório de Pesquisa Experimental em Ginecologia e Obstetrícia, Distrito de Rubião Júnior, s/n, 18610-879 Botucatu, SP, Brazil.
Abstract:
Pregestational hyperglycemia cause adverse effects on mothers and their offspring. We aimed to evaluate the maternal hyperglycemia influence on pre-embryos from diabetic rats and on their generations (daughters and granddaughters). Diabetes was induced in Sprague-Dawley rats. The mothers and their female pups were submitted to oral glucose tolerance test in adulthood. In day 4 of pregnancy, pre-embryos were collected for morphological analysis. The diabetic mother, daughter and granddaughter rats showed glucose intolerance and their pre-embryos presented developmental delay, degeneration and losses compared to the nondiabetic group. Thus, maternal diabetes transgenerationally affects embryos at early development, which contributes for embryofetal losses.
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...