SYSTEMATIC REVIEW AND META - ANALYSIS OF THE FREQUENCY AND RE-CLASSIFICATION TRENDS OF PEDIATRIC INFLAMMATORY BOWEL
Rishi Bolia1, Akhil Dhanesh Goel2
1Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Brisbane, Australia.
Arquivos De Gastroenterologia
|December 14, 2022
Summary
Inflammatory bowel disease-unclassified (IBDU) affects 7.1% of pediatric patients. Half of these children are later reclassified as ulcerative colitis (UC) or Crohn's disease (CD).
Area of Science:
- Gastroenterology
- Pediatric Gastroenterology
- Inflammatory Bowel Disease Research
Background:
- Inflammatory bowel disease-unclassified (IBDU) describes chronic colitis lacking definitive classification as ulcerative colitis (UC) or Crohn's disease (CD).
- A significant proportion of pediatric IBDU cases are reclassified upon further observation.
- Variability exists in published data regarding the frequency and reclassification rates of pediatric IBDU.
Approach:
- A systematic literature search was conducted on PubMed and Scopus for studies published between January 2014 and July 2021.
- Two independent reviewers selected studies reporting on the frequency and/or reclassification of pediatric IBDU.
- Meta-analysis using an inverse variance heterogeneity model was employed to pool prevalence data.
Key Points:
- The pooled frequency of IBDU among 16,064 pediatric patients was 7.1% (95% CI 5.8-8.5%).
- Geographical location did not influence the frequency of IBDU.
- In a subset of 5,880 patients, 50% (95% CI 41-60%) of children initially diagnosed with IBDU were reclassified on follow-up.
Conclusions:
- IBDU represents 7.1% of pediatric inflammatory bowel disease diagnoses.
- Approximately 50% of pediatric IBDU cases are reclassified to either UC or CD during follow-up.
- Children with IBDU show a higher likelihood of being reclassified to UC than to CD.
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