A sensing platform based on Cu-MOF encapsulated Dawson-type polyoxometalate crystal material for electrochemical...

A promising sensing platform based on polyoxometalate-based metal-organic framework (POMOF) was established for sensitive electrochemical detection of xanthine (XA). In the unique structure of POMOF, the Dawson polyoxoanions P₂W₁₈ were encapsulated into 3D open copper-mixed ligand nanotube framework Cu-MOF, in which the cavity of the metal-organic framework provides a specific shelter to prevent the aggregation and loss of polyoxometalate in electrocatalytic reactions; meanwhile, unsaturated Cu(II) active sites of Cu-MOF can also serve as electrocatalytic active center. The POMOF-based sensor (CuMOFP₂W₁₈/XC-72R) was fabricated by using acetylene black (XC-72R) as a support material to enhance the conductivity of POMOF. The performances of the POMOF-based sensor were studied by using different electrochemical testing methods. The composite displayed remarkable electrocatalytic activity for the oxidation of XA due to the synergistic effect of polyoxometalate (POM) and metal-organic framework (MOF). The electrochemical sensor demonstrated a wide linear range (0.5 μM-240 μM), low detection limit (0.26 μM), and excellent selectivity for detecting XA. Furthermore, the composite further demonstrated excellent reproducibility and great stability. More importantly, the proposed sensor was utilized to detect XA in real samples, which may provide a new way for early disease diagnosis.