Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

5.5K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.5K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.1K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.1K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K
Transcription Factors02:16

Transcription Factors

76.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
76.3K
Pleiotropy01:33

Pleiotropy

40.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.8K
Heterochromatin02:38

Heterochromatin

14.1K
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis.

Nature communications·2025
Same author

Autonomous function of Antennapedia in adult muscle precursors directly connects Hox genes to adult muscle development.

Development (Cambridge, England)·2025
Same author

Comprehensive Predictions of Mef2-Mediated Chromatin Loops, Which May Inhibit Ubx Binding by Blocking Low-Affinity Binding Sites.

Journal of developmental biology·2024
Same author

Canalizing cell fate by transcriptional repression.

Molecular systems biology·2024
Same author

The birth of evo-devo.

Nature reviews. Molecular cell biology·2023
Same author

Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.

Nature communications·2022
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Aug 17, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.4K

Hox function and specificity - A tissue centric view.

Pedro B Pinto1, Katrin Domsch2, Ingrid Lohmann2

  • 1Heidelberg University, Centre for Organismal Studies (COS) Heidelberg, Department of Developmental Biology and Cell Networks - Cluster of Excellence, Heidelberg, Germany; Institut de Génomique Fonctionnelle de Lyon, Univ Lyon, CNRS UMR 5242, École Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Seminars in Cell & Developmental Biology
|December 14, 2022
PubMed
Summary
This summary is machine-generated.

Hox genes reprogram body regions through homeosis. New research reveals their roles in ectoderm and mesoderm development, focusing on gene regulation, repression, and silencing for tissue morphogenesis.

Keywords:
AP-2ActivationBiFCBioIDDllEctodermEnhancerFat bodyGrhHoxInteractomesMesodermPolycombRepressionSalSpecificitySvbTinVvl

More Related Videos

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

5.9K
A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.3K

Related Experiment Videos

Last Updated: Aug 17, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.4K
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

5.9K
A Rapid In Vivo Bioassay for Developmentally Active Enhancers
00:08

A Rapid In Vivo Bioassay for Developmentally Active Enhancers

1.3K

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Hox genes are master regulators of animal body plan development.
  • They control segment identity and are conserved across many species.
  • Homeosis, the transformation of one body part into another, is a key phenomenon associated with Hox gene function.

Purpose of the Study:

  • To review recent insights into Hox protein function in ectoderm and mesoderm.
  • To discuss new findings on Hox target gene regulation and transcriptional repression.
  • To summarize the role of Hox-mediated gene silencing in tissue development.

Main Methods:

  • Literature review focusing on recent research in developmental biology.
  • Analysis of molecular mechanisms underlying Hox gene regulation.
  • Synthesis of findings on Hox interactors and their role in tissue specificity.

Main Results:

  • New findings illuminate Hox protein functions in ectoderm and mesoderm germ layers.
  • Mechanisms of transcriptional repression and gene silencing by Hox proteins are highlighted.
  • Identification of numerous tissue-specific Hox interactor partners provides new insights.

Conclusions:

  • Hox genes play critical roles in controlling tissue morphogenesis through precise gene regulation.
  • Understanding Hox-mediated gene silencing is crucial for comprehending tissue development.
  • Tissue-specific Hox interactors offer promising avenues for future research into Hox gene specificity.