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Insights from the p53 induced TIGAR protein 2 in the glycolytic pathway model

Mohammad Jahoor Alam1

  • 1Department of Biology, College of Science, University of Hail, Kingdom of Saudi Arabia.

Bioinformation
|December 15, 2022
PubMed

Insights

The tumor suppressor p53 influences cellular metabolism through the TIGAR gene. Increased TIGAR protein levels, induced by p53, suppress oscillations in the glycolytic pathway, aligning with experimental findings.

Area of Science:

  • Biochemistry
  • Systems Biology
  • Molecular Biology

Background:

  • The tumor suppressor protein p53 regulates cellular metabolism.
  • TIGAR (TP53-induced glycolysis regulator) is a p53-inducible gene impacting glycolysis.
  • TIGAR reduces fructose-2,6-bisphosphate, inhibiting glycolysis and decreasing reactive oxygen species (ROS).

Purpose of the Study:

  • To investigate the role of p53-induced TIGAR protein in the glycolytic pathway.
  • To model the interplay between the p53-Mdm2 network and the glycolytic pathway incorporating TIGAR.

Main Methods:

  • Development of a two-oscillator mathematical model.
  • Numerical and stochastic simulations of the p53-Mdm2-TIGAR-glycolysis network.

Main Results:

  • Model simulations demonstrate that elevated TIGAR protein levels suppress oscillations in the glycolytic pathway.
  • The simulation results are consistent with experimental observations.

Conclusions:

  • The p53-TIGAR interaction plays a significant role in regulating glycolytic dynamics.
  • Stochastic simulations provide insights into the realistic behavior of metabolic pathways.
Keywords:
Glycolytic pathwayOscillationTIGARnumerical simulationp53

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