Related Experiment Video
Updated: Aug 10, 2026

09:06
Manipulation of Epileptiform Electrocorticograms (ECoGs) and Sleep in Rats and Mice by Acupuncture
Published on: December 22, 2016
8-Cyclopentyl 1,3-dimethylxanthine prolongs epileptic seizures in rats
1Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, N.S., Canada.
Brain Research
|August 11, 1987
Abstract:
We tested the effects of 8-cyclopentyl-1,3 dimethylxanthine (8-CPT) on electrically induced seizures in rats. 8-CPT prolonged secondary seizures and converted partial seizures into generalized motor seizures, but did not affect primary seizure duration. Because 8-CPT is a potent and specific adenosine antagonist, these results add further support to the hypothesis that endogenous adenosine prevents the spread of epileptic seizures.

